Fadrozole

SKU: orb1299988

Description

Fadrozole is a potent nonsteroidal aromatase inhibitor (IC50: 6.4 nM) with antineoplastic properties. It is widely used in research to study estrogen-dependent cancers, such as breast cancer, in both in vitro assays and in vivo animal models.

Research Area

Metabolism Research, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 102676-47-1
• MW: 223.27
• Purity: 99.47% (May vary between batches)
• Formula: C₁₄H₁₃N₃
• SMILES: N#Cc1ccc(cc1)C1CCCc2cncn12
• Target: Aromatase,Cytochromes P450
• Solubility: DMSO:100 mg/mL (447.89 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (17.92 mM)

Bioactivity

• Target IC50:
  Aromatase:6.4 nM
• In Vivo:
  Fadrozole is a model aromatase inhibitor that shown to suppress estrogen production in the ovaries of fish.
• Animal Research:
  Adult female fathead minnows (Pimephales promelas) were exposed via water to 0, 5, or 50μg fadrozole/L for a time-course of 0.5, 1, 2, 4, and 6h, or 0 or 50μg fadrozole/L for a time-course of 6, 12, and 24h. Examined ex vivo ovarian 17β-estradiol (E2) and testosterone (T) production, and plasma E2 concentrations from each study.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Aromatase, (Rac)-FAD286, CGS 16949A, inhibit, Fadrozole, Inhibitor

Compound Identifiers

PubChem CID

59693