Fadrozole hydrochloride

SKU: orb1299712

Description

Fadrozole hydrochloride (CGS 16949A) is a potent and selective non-steroidal aromatase inhibitor. It is widely used in research to study estrogen biosynthesis, with applications in both in vitro enzyme assays and in vivo models, such as in fish, to investigate endocrine disruption and reproductive physiology.

Research Area

Metabolism Research

Key Properties

• CAS Number: 102676-31-3
• MW: 259.73
• Purity: 98.00%
• Formula: C₁₄H₁₄ClN₃
• SMILES: Cl.N#Cc1ccc(cc1)C1CCCc2cncn12
• Target: Aromatase,Cytochromes P450
• Solubility: DMSO:100 mg/mL (385.02 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (15.4 mM);H2O:100 mg/mL (385.02 mM)

Bioactivity

• Target IC50:
  Aromatase:1.4 nM (rat)|Aromatase:5 nM(human)
• In Vivo:
  Fadrozole hydrochloride inhibits growth of androstenedione-stimulated mammary D2 cells implanted into thoracic mammary fat pads of mice by 95% when administered at a dose of 0.5 mg per animal per day.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

inhibit, Estrogen, Fadrozole, Fadrozole hydrochloride, Fadrozole Hydrochloride, Inhibitor, (Rac)-FAD286, Aromatase, CGS 16949A, progesterone, spontaneous tumour, P-450

Compound Identifiers

PubChem CID

59694