EX 527 (Selisistat)

SKU: orb1224939

Description

EX 527 is a potent and selective SIRT1 inhibitor with IC50 of 38 nM, exhibits >200-fold selectivity against SIRT2 and SIRT3.(In Vitro):Selisistat (1-10 μM) inhibits the deacetylation activity of both human SirT1 and Drosophila Sir2 in transfected cells.(In Vivo):Selisistat (5 and 20 mg/kg, PO, daily; transgenic R6/2 mice beginning at 4.5 weeksof age to death) is protective in the R6/2 mouse model of Huntington’s disease (HD).

Key Properties

• CAS Number: 49843-98-3
• MW: 248.71
• Purity: >98% (HPLC)
• Formula: C₁₃H₁₃ClN₂O
• SMILES: O=C(C1C(NC2=C3C=C(Cl)C=C2)=C3CCC1)N
• Target: Sirtuin
• Solubility: DMSO:50 mg/mL (201.03 mM); Ethanol:18 mg/mL (72.37 mM); Water:<1 mg/mL (<1 mM)

Bioactivity

• In Vivo:
  Selisistat (5 and 20 mg/kg, PO, daily; transgenic R6/2 mice beginning at 4.5 weeksof age to death) is protective in the R6/2 mouse model of Huntington’s disease (HD).
• In Vitro:
  Selisistat (1-10 μM) inhibits the deacetylation activity of both human SirT1 and Drosophila Sir2 in transfected cells.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Selisistat

Quick Database Links

Gene Symbol

Sirtuin