Selisistat R-enantiomer

SKU: orb1308316

Description

EX-527 (R-enantiomer) is the less active enantiomer of the SIRT1 inhibitor Selisistat, exhibiting an IC50 > 100 μM against SIRT1. It serves as a critical negative control compound in biochemical and cellular research to validate the stereospecific activity of the active S-enantiomer in studies related to aging and neurodegenerative diseases.

Research Area

Epigenetics & Chromatin, Molecular Biology

Key Properties

• CAS Number: 848193-69-1
• MW: 248.71
• Purity: 99.80% (May vary between batches)
• Formula: C₁₃H₁₃ClN₂O
• SMILES: NC(=O)[C@@H]1CCCc2c1[nH]c1ccc(Cl)cc21
• Target: Sirtuin
• Solubility: DMSO:100 mg/mL (402.07 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (16.08 mM)

Bioactivity

• Target IC50:
  SIRT1:> 100 μM

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

(R)-Selisistat, inhibit, Inhibitor, EX 527, EX527, EX-527, EX-527 (R-enantiomer), Selisistat R enantiomer, Selisistat Renantiomer, Selisistat R-enantiomer, SIRT1, Sirtuin

Compound Identifiers

PubChem CID

707032