Evodiamine

SKU: orb1304910

Description

Evodiamine is a bioactive alkaloid derived from the fruit of Evodia rutaecarpa, exhibiting anti-inflammatory, anti-obesity, and anti-tumor properties. It is widely used in pharmacological research, with studies demonstrating its efficacy in both in vitro cell-based assays and in vivo animal models for cancer and metabolic diseases.

Research Area

Cardiovascular Research, Cell Biology, Neuroscience

Key Properties

• CAS Number: 518-17-2
• MW: 303.36
• Purity: >98%
• Formula: C₁₉H₁₇N₃O
• SMILES: CN1[C@@]2(C3=C(C=4C(N3)=CC=CC4)CCN2C(=O)C=5C1=CC=CC5)[H]
• Target: Ion channel
• Solubility: Soluble in DMSO (up to 5 mg/ml).

Bioactivity

• In Vivo:
  In U937 cells with overexpressed Bcl-2 and Akt, evodiamine induces apoptosis through a caspase-independent cell death pathway.
• In Vitro:
  In mice, the LD50 of intravenously injected Evodiamine is 77 mg/kg.
• Cell Research:
  Evodiamine is dissolved in DMSO and diluted with appropriate medium before use. The evodiamine-inspired new scaffolds are assayed for growth inhibitory activities toward human cancer cell-lines A549 (lung cancer), MDA-MB-435 (breast cancer) and HCT116 (colon cancer) using the MTT assay. Evodiamine and camptithecin are used as reference drugs.

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Isoevodiamine, Evodiamine, d-Evodiamine, (+)-Evodiamine, PGE, ProstaglandinReceptor, Prostaglandin Receptor

Compound Identifiers

PubChem CID

442088