Estrogen receptor modulator 1

SKU: orb1308325

Description

Estrogen receptor modulator 1 is an orally bioavailable SERM (pIC50: 0.46) that induces regression of hormone-independent, Tamoxifen-resistant tumors in xenograft models. It is a research tool for studying advanced breast cancer mechanisms and evaluating novel endocrine therapies in both in vitro and in vivo experimental settings.

Research Area

Metabolism Research

Key Properties

• CAS Number: 63676-22-2
• MW: 242.29
• Purity: 98.14% (May vary between batches)
• Formula: C₁₄H₁₀O₂S
• SMILES: Oc1ccc(cc1)-c1cc2ccc(O)cc2s1
• Target: Estrogen Receptor/ERR
• Solubility: DMSO:50 mg/mL (206.36 mM)

Bioactivity

• In Vivo:
  Estrogen receptor modulator 1 (1.5 mg/animal; p.o.; daily for 2 weeks) induces regression of T47D:A18/PKCα tumors .
• In Vitro:
  Estrogen receptor modulator 1 (100 nM; 9 days) obviously inhibits the growth of MCF-7:5C cell. It also causes apoptosis in these cells 6 days. Estrogen receptor modulator 1 (100 nM; 10 days) inhibits T47D:A18/PKCα and T47D:A18-TAM1 colony formation .
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

cells, breast, cancer, athymic, inhibit, mice, ERR, EstrogenReceptor, Estrogen Receptor/ERR, Estrogen receptor modulator 1, Estrogen receptor modulator1, Estrogen receptor modulator-1, Estrogen Receptor, Inhibitor, MCF-7:5C, selective, tumor

Compound Identifiers

PubChem CID

445920