Esonarimod

SKU: orb1302993

Description

Esonarimod

Research Area

Immunology & Inflammation

Key Properties

• CAS Number: 101973-77-7
• MW: 280.34
• Purity: 97.44%
• Formula: C₁₄H₁₆O₄S
• SMILES: CC(=O)SCC(CC(=O)c1ccc(C)cc1)C(O)=O
• Target: Others,IL Receptor
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (7.13 mM);DMSO:60 mg/mL (214.03 mM)

Bioactivity

• In Vivo:
  After repeated oral administration of Esonarimod (14C-KE-298), the radioactivity rapidly decreases with no accumulation observed.
• In Vitro:
  The IC50 of Esonarimod is 117.5 μg/mL. In RAW264.7 cells, Esonarimod (KE-298) (10 to 300 μg/mL) suppresses the production of NO in a dose-dependent manner.
• Cell Research:
  For in vitro experiment, Esonarimod (KE-298) is dissolved in ethanol and diluted with culture medium or distilled water.RAW264.7 cells are used in this study. For NO production, RAW264.7 cells [2×105/0.2 mL of RPMI-1640 supplemented by 10% heat inactivated fetal bovine serum (FBS), penicillin G (100 U/mL), and streptomycin (100 μg/mL)] are stimulated with 100 ng/mL of Escherichia coli 026:B6 lipopolysaccharide in the presence of Esonarimod (KE-298) (0, 10, 30, 100, 200, 300 μg/mL) in 96 well plates and incubated 24 h at 37°C in an atmosphere of 5% CO2 in air. After incubation, the supernatants are collected and assayed for nitrite (NO2-) instead of NO.
• Animal Research:
  Seven-week-old male Wistar rats is administered Esonarimod (5 mg/kg once daily) orally by gastric intubation.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Inhibitor, Esonarimod, IL Receptor, IL-1, ILReceptor, KE 298, KE298, KE-298, inhibit

Compound Identifiers

PubChem CID

127998