Esonarimod

SKU: orb1222927

Description

Esonarimod is an antirheumatic drug, suppressing lymphocyte activating factor activity or biosynthesis.(In Vitro):Esonarimod (KE-298) (10 to 300 μg/mL) suppresses the production of NO by RAW264.7 cells in a dose dependent manner. The IC50 of Esonarimod is 117.5 μg/mL. Esonarimod does not affect cellular viability at these tested doses. Esonarimod has no direct effect on NOS activity in cell-free extracts of RAW264.7 cells.(In Vivo):After repeated oral administration of Esonarimod (14C-KE-298), the radioactivity decreases rapidly and no tendency towards accumulation is found.

Key Properties

• CAS Number: 101973-77-7
• MW: 280.34
• Purity: >98% (HPLC)
• Formula: C₁₄H₁₆O₄S
• SMILES: CC1=CC=C(C=C1)C(=O)CC(CSC(=O)C)C(=O)O
• Target: IL-1

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Esonarimod | KE-298 | KE298

Quick Database Links

Gene Symbol

IL-1