Eseroline

SKU: orb3174281

Description

Eseroline is a potent μ-opioid receptor agonist and a hydrolytic metabolite of Physostigmine. It serves as a selective and competitive acetylcholinesterase (AChE) inhibitor, with inhibition constants (Ki) of 0.1 μM for AChE and 200 μM for butyrylcholinesterase (BuChE). Eseroline acts as an allosteric potentiating ligand of nicotinic acetylcholine receptors (nAChR-APL), enhancing Ach-induced nAChR signaling without directly activating the receptor. The compound is neurotoxic, causing cellular membrane damage (LDH leakage) and energy metabolism collapse (ATP depletion). Additionally, Eseroline can be utilized in Alzheimer's disease research.

Research Area

Metabolism Research, Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 469-22-7
• MW: 218.3
• Formula: C₁₃H₁₈N₂O
• SMILES: C[C@]12C=3C(N(C)[C@]1(N(C)CC2)[H])=CC=C(O)C3
• Target: Opioid Receptor,AChR,Drug Metabolite,Cholinesterase (ChE)

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Opioid Receptor,AChR,Drug Metabolite,Cholinesterase (ChE)