Esculeoside A

SKU: orb3211874

Description

Esculeoside A is an orally active spirastan steroidal alkaloid glycoside found in the ripe fruits of Lycopersicon esculentum var. cerasiforme and Lycopersicon esculentum. It serves as a cardioprotective and hypoglycemic agent. Esculeoside A modulates the NF-κB and Nrf2/Keap1 signaling pathways in cardiac tissues, reducing inflammation and apoptosis while preventing cardiomyocyte hypertrophy and lowering serum lipid levels. It also regulates glucose metabolism by modulating the expression of IRS-1, GCK, AMPK, and PEPCK, ultimately lowering fasting blood glucose and enhancing glucose tolerance. Furthermore, Esculeoside A inhibits the TLR4/p-NFκB signaling pathway, hindering dendritic cell maturation and allogeneic T cell proliferation, while suppressing the growth of breast cancer and melanoma cells. Additionally, it inhibits ACAT activity, thereby reducing cholesterol ester accumulation in macrophages. Esculeoside A is relevant for research into diabetic cardiomyopathy, type 2 diabetes, atopic dermatitis, tumors, and atherosclerotic diseases.

Key Properties

• CAS Number: 532387-86-3
• MW: 1270.36
• Formula: C₅₈H₉₅NO₂₉
• SMILES: C[C@@H]1[C@]2(O[C@@]3([C@]1([C@]4(C)[C@@](C3)([C@]5([C@](CC4)([C@]6(C)[C@@](CC5)(C[C@@H](O[C@@H]7O[C@H](CO)[C@H](O[C@H]8[C@H](O[C@@H]9O[C@H](CO)[C@@H](O)[C@H](O)[C@H]9O)[C@@H](O[C@H]%10[C@H](O)[C@@H](O)[C@H](O)CO%10)[C@H](O)[C@@H](CO)O8)[C@H](O)[C@H]7O)CC6)[H])[H])[H])[H])[H])[H])[C@@H](OC(C)=O)C[C@H](CO[C@@H]%11O[C@H](CO)[C@@H](O)[C@H](O)[C@H]%11O)CN2
• Target: AMPK,Nrf2,IGF-1R,NF-κB,TLR

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

AMPK,Nrf2,IGF-1R,NF-κB,TLR