Esculeogenin A

SKU: orb3211810

Description

Esculeogenin A is the aglycone of the tomato saponin, Esculeoside A. It is an orally active compound with hepatoprotective, lipid-lowering, and antioxidant properties. Esculeogenin A regulates molecular targets such as PPARα, SREBP1, Nrf2, NF-κB, and ACAT1/ACAT2, promoting hepatic fatty acid oxidation, inhibiting de novo lipogenesis, enhancing antioxidant defense, and suppressing inflammatory responses. It improves liver function, alleviates hyperlipidemia, and inhibits hepatic steatosis and foam cell formation. Additionally, it prevents non-alcoholic fatty liver disease in high-fat diet-fed rats and reduces atherosclerotic lesions in apoE-deficient mice. Esculeogenin A is useful for research related to non-alcoholic fatty liver disease, atherosclerosis, and hyperlipidemia.

Key Properties

• CAS Number: 854381-37-6
• MW: 447.65
• Formula: C₂₇H₄₅NO₄
• SMILES: C[C@@H]1[C@]2(O[C@@]3([C@]1([C@]4(C)[C@@](C3)([C@]5([C@](CC4)([C@]6(C)[C@@](CC5)(C[C@@H](O)CC6)[H])[H])[H])[H])[H])[H])[C@H](O)C[C@H](CO)CN2
• Target: PPAR,Nrf2,Fatty Acid Synthase,Acyltransferase,NF-κB

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

PPAR,Nrf2,Fatty Acid Synthase,Acyltransferase,NF-κB