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ERK5-IN-1

SKU: orb1221172

Description

ERK5-IN-1 is a potent ERK5 inhibitor (IC50: 87 nM). It also inhibits LRRK2[G2019S] (IC50: 26 nM).

Research Area

Stem Cell & Developmental Biology

Images & Validation

Key Properties

CAS Number1234479-76-5
MW459.54
Purity>98% (HPLC)
FormulaC25H29N7O2
SMILESCOc1cc(ccc1Nc1ncc2N(C)C(=O)c3ccccc3N(C)c2n1)N1CCN(C)CC1
TargetERK
SolubilityDMSO: 10 mM

Bioactivity

In Vitro
ERK5-IN-1 (Compound 5) exhibits a cellular EC50 for inhibiting epidermal growth factor (EGF) induced ERK5 autophosphorylation of 0.19±0.04 μM.

Storage & Handling

StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

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ERK5-IN-1 (orb1221172)

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% DMSO +
%+
% Tween 80 +
%

Available Sizes

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200 mg
500 mg
5 mg
$ 190.00
10 mg
$ 250.00
25 mg
$ 410.00
50 mg
$ 690.00
100 mg
$ 960.00