ERK1/2 inhibitor 1

SKU: orb1709744

Description

ERK1/2 inhibitor 1 is a potent and orally active small molecule that selectively inhibits ERK1 and ERK2 with an IC50 of 3.0 nM. It is widely used in cancer research to study MAPK/ERK pathway signaling in both cellular assays and in vivo models.

Research Area

Pharmacology & Drug Discovery; Cell Biology, Signal Transduction

Key Properties

• CAS Number: 2095719-90-5
• MW: 550.05
• Purity: 99.09% (May vary between batches)
• Formula: C₂₉H₃₂ClN₅O₄
• SMILES: C[C@@H](N1Cc2ccc(cc2C1=O)-c1nc(NC2CCOCC2)ncc1Cl)C(=O)N[C@H](CO)c1cccc(C)c1
• Target: ERK
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (1.82 mM);DMSO:5.51 mg/mL (10.02 mM)

Bioactivity

• Target IC50:
  ERK1:|ERK2:3.0 nM
• In Vitro:
  ERK1/2 inhibitor 1 shows excellent antiproliferative potency with IC50s of 7.5 and 4.9 nM in Colo205 cells and A375, respectively.

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

ERK1, ERK1/2 inhibitor 1, ERK-1/2 inhibitor 1, ERK2

Compound Identifiers

PubChem CID

129053491