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ERK1/2 inhibitor 1

SKU: orb1709744

Description

ERK1/2 inhibitor 1 is a potent and orally active small molecule that selectively inhibits ERK1 and ERK2 with an IC50 of 3.0 nM. It is widely used in cancer research to study MAPK/ERK pathway signaling in both cellular assays and in vivo models.

Research Area

Pharmacology & Drug Discovery; Cell Biology

Images & Validation

Key Properties

CAS Number2095719-90-5
MW550.05
Purity99.09% (May vary between batches)
FormulaC29H32ClN5O4
SMILESC[C@@H](N1Cc2ccc(cc2C1=O)-c1nc(NC2CCOCC2)ncc1Cl)C(=O)N[C@H](CO)c1cccc(C)c1
TargetERK
Solubility10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (1.82 mM);DMSO:5.51 mg/mL (10.02 mM)

Bioactivity

Target IC50
ERK1:|ERK2:3.0 nM
In Vitro
ERK1/2 inhibitor 1 shows excellent antiproliferative potency with IC50s of 7.5 and 4.9 nM in Colo205 cells and A375, respectively.

Storage & Handling

StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

ERK1, ERK1/2 inhibitor 1, ERK-1/2 inhibitor 1, ERK2

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Key Properties

No computed properties available.

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Protocol Information

ERK1/2 inhibitor 1 (orb1709744)

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% DMSO +
%+
% Tween 80 +
%

Available Sizes

Select a size below

1 mg
$ 170.00
5 mg
$ 370.00
1 ml x 10 mM (in DMSO)
$ 400.00
10 mg
$ 510.00
25 mg
$ 760.00
50 mg
$ 1,000.00
100 mg
$ 1,340.00
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