Epieriocalyxin A

SKU: orb1297104

Description

Epieriocalyxin A

Research Area

Cell Biology, Immunology & Inflammation, Molecular Biology, Protein Biochemistry, Signal Transduction

Key Properties

• CAS Number: 191545-24-1
• MW: 344.4
• Purity: 97.00% (May vary between batches)
• Formula: C₂₀H₂₄O₅
• SMILES: C(=O)[C@H]1[C@]2([C@]3([C@]4(C[C@@](CC3)([C@@H](C)C4=O)[H])C(=O)OC2)[H])C(=O)C=CC1(C)C
• Target: DNA/RNA Synthesis,ROS,ERK,Bcl-2 Family,Apoptosis,Caspase,JNK

Bioactivity

• In Vitro:
  Epieriocalyxin A (EpiA), a diterpenoid isolated from I. eriocalyx, suppressed Caco-2 colon cancer cell growth. EpiA induced annexin V flipping in the cell membrane and DNA fragment. We also showed that EpiA induced the generation of ROS in cells, as well as damage of the mitochondrial membrane. Western blot results showed that both JNK and ERK1/2 activation was decreased after EpiA treatment in a dose-dependent manner. EpiA increased the expression of caspase 3 and Bax and decreased Bcl2 expression.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

colon cancer, Caspase, DNA/RNA Synthesis, DNA Synthesis, diterpenoid, DNASynthesis, Apoptosis, Bcl-2, inhibit, JNK, Inhibitor, ERK1/2, ERK, Extracellular signal regulated kinases, Epieriocalyxin A, epi-Eriocalyxin A, ROS, RNA Synthesis, RNASynthesis

Compound Identifiers

PubChem CID

124350731