ER covalent antagonist-1

SKU: orb2945325

Description

ER covalent antagonist-1 (Compound 39D) is a covalent ERα antagonist that inhibits MCF-7 cell proliferation (IC50 = 0.98 µM), induces G0/G1 arrest and apoptosis in vitro, and shows in vivo antitumor efficacy in mouse models, supporting breast cancer research.

Research Area

Cell Biology, Metabolism Research, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 2757498-74-9
• MW: 568.683
• Formula: C₃₃H₃₂N₂O₅S
• SMILES: O(C1=C(C(=O)C2=CC=CC=C2)SC=3C1=CC=C(O)C3)C4=CC=C(OC5CN(C/C=C/C(=O)N6CCCCC6)C5)C=C4
• Target: Apoptosis,Estrogen Receptor/ERR

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

162516286