Epiberberine

SKU: orb1301237

Description

Epiberberine is a research compound with noted CYP2D6-mediated drug interaction potential. It exhibits anti-adipogenic effects in 3T3-L1 cells via modulation of Raf/MEK/ERK and AMPKα/Akt pathways and serves as a fluorescent probe for studying G-quadruplex DNA structures.

Research Area

Epigenetics & Chromatin, Neuroscience, Signal Transduction

Key Properties

• CAS Number: 6873-09-2
• MW: 336.36
• Purity: 99.47%
• Formula: C₂₀H₁₈NO₄
• SMILES: O(C)C=1C=C2C=3[N+](=CC4=C(C3)C=CC5=C4OCO5)CCC2=CC1OC
• Target: AChR,BACE,Beta-Secretase,MEK,AMPK,ERK,Cholinesterase (ChE)
• Solubility: DMSO:3.52 mg/mL (10.46 mM);Chloroform, Dichloromethane, Ethyl Acetate, Acetone, etc.:Soluble

Bioactivity

• Target IC50:
  AChE:1.07 μM|BACE1:8.55 μM|BChE:6.03μM

Storage & Handling

• Storage: keep away from direct sunlight,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

BACE1, BACE, BChE, BetaSecretase, Beta-secretase, bSecretase, b-Secretase, AChE, Cholinesterase (ChE), Inhibitor, inhibit, Epiberberine, ERK1, ERK3, MEK1, β-Secretase, βSecretase

Compound Identifiers

PubChem CID

160876