Epiberberine chloride

SKU: orb1685391

Description

Epiberberine chloride

Research Area

Immunology & Inflammation, Metabolism Research, Neuroscience, Signal Transduction

Key Properties

• CAS Number: 889665-86-5
• MW: 371.81
• Purity: 99.89%
• Formula: C₂₀H₁₈ClNO₄
• SMILES: [Cl-].COc1cc2CC[n+]3cc4c5OCOc5ccc4cc3-c2cc1OC
• Target: BACE,ROS,Beta-Secretase,Reactive Oxygen Species,Antioxidant,Cholinesterase (ChE),AChR
• Solubility: 10% DMSO+90% Saline:2 mg/mL (5.38 mM);DMSO:20 mg/mL (53.79 mM)

Bioactivity

• Target IC50:
  AChE:1.07 µM|BACE1:8.55 μM|BChE:6.03 µM
• In Vivo:
  Body weight, food consumption, water intake, and urinary output of KK-Ay mice were reduced after being treated with Epiberberine (225 mg/kg, p.o. daily for 40 days).
• In Vitro:
  Epiberberine chloride has antioxidant activity, with peroxynitrite ONOO- scavenging effect (IC50, 16.83 μM), and may protect against Alzheimer disease. Epiberberine (0, 12.5, 25, or 50 μM) dose-dependently inhibits cellular triglyceride accumulation in 3T3-L1 adipocytes (IC50: 52.8 μM). Epiberberine (12.5-50 μM) suppresses the Raf/MEK1/ERK1/2 and AMPKα/Akt pathways in the early stage of 3T3-L1 adipocyte differentiation . Epiberberine (0.2, 1, 5 μg/mL) inhibits glucose uptake in HepG2 cells in a concentration-dependent manner .

Storage & Handling

• Storage: keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Cholinesterase (ChE), AChR, AChE, Beta-secretase, Antioxidant, BACE1, BACE, Epiberberine, Epiberberine (chloride), Inhibitor, inhibit, Reactive Oxygen Species, β-Secretase

Compound Identifiers

PubChem CID

71467079