EP4 receptor antagonist 7

SKU: orb2945307

Description

EP4 receptor antagonist 7 is a potent and selective small molecule antagonist of the PGE2 EP4 receptor (IC50 = 1.1 nM). It effectively suppresses PGE2-mediated signaling and gene expression in macrophages in vitro and demonstrates synergistic antitumor activity with anti-PD-1 therapy in mouse colon cancer models by enhancing CD8+ T cell infiltration.

Research Area

Immunology & Inflammation, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 3035217-40-1
• MW: 453.413
• Formula: C₂₄H₁₈F₃N₃O₃
• SMILES: O=C(O)C1=CC=C(C=C1)CNC(=O)C2=C3C=CC=CC3=NN2CC4=CC=C(C=C4)C(F)(F)F
• Target: Interleukin,Prostaglandin Receptor

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

171361355