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Ensitrelvir

SKU: orb1940163

Description

Ensitrelvir.(In Vitro):The EC50 values for SARS-CoV and MERS-CoV were 0.21 and 1.4 μM respectively. In a cytopathic effect (cpe)-inhibition assay of SARS-CoV-2 infected VeroE6/TMPRSS2 cells, Ensitrelvir shows the EC50 values are approximately 0.4 μM for both wild-type virus and Alpha, Beta, Gamma and Delta variants.(In Vivo):Ensitrelvir inhibits intrapulmonary replication of SARS-CoV-2 in mice in a dose-dependent manner.

Images & Validation

Key Properties

CAS Number2647530-73-0
MW531.88
Purity>98% (HPLC)
FormulaC22H17ClF3N9O2
SMILESCn1nc(cc(c(/N=C(\NC(N2Cc3nn(C)cn3)=O)/N(Cc(cc(c(F)c3)F)c3F)C2=O)c2)Cl)c2c1
TargetCOX-2|5-Lipoxygenase
SolubilityIn Vitro: DMSO : 50 mg/mL (94.01 mM)

Storage & Handling

StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

S-217622

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Ensitrelvir (orb1940163)

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(Recommended: An additional animal making an allowance for loss during the experiment)

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