Ensitrelvir

SKU: orb1297924

Description

Ensitrelvir (S-217622) is an orally bioavailable 3CL protease inhibitor for SARS-CoV-2, exhibiting potent antiviral activity with an IC50 of 13 nM. It is a valuable research tool for studying coronavirus replication and has demonstrated efficacy in both in vitro assays and in vivo animal models of infection.

Research Area

Infectious Disease & Virology

Key Properties

• CAS Number: 2647530-73-0
• MW: 531.88
• Purity: 99.78%
• Formula: C₂₂H₁₇ClF₃N₉O₂
• SMILES: Cn1nc(cc(c(/N=C(\NC(N2Cc3nn(C)cn3)=O)/N(Cc(cc(c(F)c3)F)c3F)C2=O)c2)Cl)c2c1
• Target: SARS-CoV,Virus Protease
• Solubility: DMSO:160 mg/mL (300.82 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (7.52 mM)

Bioactivity

• Target IC50:
  3CLpro (SARS CoV-2):13 nM
• In Vivo:
  Ensitrelvir inhibits intrapulmonary replication of SARS-CoV-2 in mice in a dose-dependent manner.
• In Vitro:
  The EC50 values for SARS-CoV and MERS-CoV were 0.21 and 1.4 μM respectively. In a cytopathic effect (cpe)-inhibition assay of SARS-CoV-2 infected VeroE6/TMPRSS2 cells, Ensitrelvir shows the EC50 values are approximately 0.4 μM for both wild-type virus and Alpha, Beta, Gamma and Delta variants.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

S 217622, S217622, S-217622, SARS-CoV-2 3CL, SARS-CoV, SARSCoV, SARS coronavirus, Virus Protease, variant, oral, intrapulmonary replication, inhibit, Ensitrelvir, Inhibitor, COVID-19

Compound Identifiers

PubChem CID

162533924