Empesertib

SKU: orb1298892

Description

Empesertib (BAY 1161909) is a potent and selective oral Mps1 inhibitor (IC50 < 1 nM) with antineoplastic potential. It is used in cancer research to study mitotic checkpoint inhibition, demonstrating antitumor activity in both cellular assays and in vivo xenograft models.

Research Area

Signal Transduction

Key Properties

• CAS Number: 1443763-60-7
• MW: 559.61
• Purity: 99.40% (May vary between batches)
• Formula: C₂₉H₂₆FN₅O₄S
• SMILES: COc1cc(ccc1Nc1nc2ccc(cn2n1)-c1ccc(NC(=O)[C@H](C)c2ccc(F)cc2)cc1)S(C)(=O)=O
• Target: Kinesin
• Solubility: DMSO:10 mg/mL (17.87 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (1.79 mM)

Bioactivity

• Target IC50:
  Mps1:1 nM

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

BAY 1161909, BAY1161909, BAY-1161909, Empesertib, Inhibitor, inhibit, Mps1, Monopolar spindle 1

Compound Identifiers

PubChem CID

71599640