Emodin 6-O-β-D-glucoside

SKU: orb1296977

Description

Emodin 6-O-β-D-glucoside (Glucoemodin) is a bioactive compound with demonstrated anti-inflammatory properties, protecting barrier function and inhibiting HMGB1 signaling. Its research applications include investigating potential therapies for sepsis, diabetic complications, and atherosclerosis in both cellular and animal models.

Key Properties

• CAS Number: 34298-85-6
• MW: 432.38
• Purity: 98.06% (May vary between batches)
• Formula: C₂₁H₂₀O₁₀
• SMILES: Cc1cc(O)c2C(=O)c3c(O)cc(O[C@@H]4O[C@H](CO)[C@@H](O)[C@H](O)[C@H]4O)cc3C(=O)c2c1
• Target: Others
• Solubility: DMSO:65 mg/mL (150.33 mM)

Bioactivity

• In Vivo:
  Emodin-6-O-β-D-glucoside (EG) inhibits HMGB1-mediated hyperpermeability and leukocyte migration in mice, and increases the survival times of CLP-administered mice.
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• In Vitro:
  Emodin-6-O-β-D-glucoside (EG), a novel active compound from Reynoutria japonica, suppresses HMGB1 release, TNF-α production, and HMGB1-induced NF-κB activation in HUVECs.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

complications, diabetic, barrier, anti-inflammatory, atherosclerosis, active, inhibit, japonica, Inhibitor, Glucoemodin, Emodin 6 O β D glucoside, Emodin 6-O-b-D-glucoside, Emodin 6-O-beta-D-glucoside, Emodin 6OβDglucoside, Emodin 6-O-β-D-glucoside, potent, protective, Reynoutria

Compound Identifiers

PubChem CID

5317038