Emodin 6-O-β-D-glucoside

SKU: orb1218133

Description

Emodin 6-O-β-D-glucoside can protect barrier integrity and inhibit HMGB1-mediated inflammatory responses, which suggests a potential use as a therapy for sepsis or septic shock. Emodin 6-O-beta-D-glucoside has anti-inflammatory activities and also may have significant therapeutic benefits against diabetic complications and atherosclerosis.

Key Properties

• CAS Number: 34298-85-6
• MW: 432.38
• Purity: >98% (HPLC)
• Formula: C₂₁H₂₀O₁₀
• SMILES: Cc(cc1C(c2cc(O[C@@H]([C@@H]([C@H]3O)O)O[C@H](CO)[C@H]3O)cc(O)c22)=O)cc(O)c1C2=O
• Target: Others

Bioactivity

• In Vivo:
  Emodin-6-O-β-D-glucoside (0~9 mg/mouse; i. v.) markly inhibits peritoneal leakage of dye induced by high glucose. Animal model: Mouse. Dosage: 0~9 mg/mouse. Administration: I. v. Result: Markly inhibited peritoneal leakage of dye induced by high glucose.
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• In Vitro:
  Emodin-6-O-β-D-glucoside (0~20 μM; 24 hours; HUVECs) does not affect cell viability. Emodin-6-O-β-D-glucoside (0~10 μM; 6 hours; HUVECs) results in a dose dependent decrease in high glucose-mediated membrane disruption, inhibits high glucose-induced increase expression of VCAM-1, ICAM-1 and E-selectin and results in decreased expression levels of high glucose-induced MCP-1 and IL-8 mRNA. Emodin-6-O-β-D-glucoside (10 μM; 6 hours; HUVECs) results in a decrease in the number of THP-1 cells adhering to high glucose-induced HUVECs. Emodin-6-O-β-D-glucoside pretreatment significantly inhibits high-glucose-induced ROS formation and p65 NF-κB expression levels increase. Cell Viability Assay Cell line: HUVECs. Concentration: 0~20 μM. Incubation time: 24 hours. Result: Did not affect cell viability. Western blot analysis. Cell line: HUVECs. Concentration: 0~10 μM. Incubation time: 6 hours. Result: Inhibited high glucose-induced increase expression of VCAM-1, ICAM-1 and E-selectin. RT-PCR Cell line: HUVECs. Concentration: 0~10 μM. Incubation time: 6 hours. Result: Resulted in decreased expression levels of high glucose-induced MCP-1 and IL-8 mRNA. Immunofluorescence Cell line: HUVECs. Concentration: 10 μM. Incubation time: 6 hours. Result: Resulted in a decrease in the number of THP-1 cells adhering to high glucose-induced HUVECs.
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Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Glucoemodin

Quick Database Links

Gene Symbol

Others