Emlenoflast

SKU: orb1218519

Description

Emlenoflast is a potent and selective inhibitor of NLRP3 inflammasome.

Key Properties

• CAS Number: 1995067-59-8
• MW: 388.48
• Purity: >98% (HPLC)
• Formula: C₁₉H₂₄N₄O₃S
• SMILES: O=S(C1=NN(C(C)C)C=C1)(NC(NC2=C3CCCC3=CC4=C2CCC4)=O)=O
• Target: NOD
• Solubility: In Vitro: DMSO : 125 mg/mL (321.77 mM)

Bioactivity

• In Vivo:
  Emlenoflast (4 mg/kg; i. v.) exhibits the half-life (3.39 h), AUC0-last (107097 ng h/mL) and CL (0.621 mL/min/kg) in mice. Emlenoflast (20 mg/kg; p.o.) exhibits the oral bioavailability (67.2%), Cmax (60467 ng/mL) and half-life (5.02 h) in mice. Animal model: Male C57BL/6 mice (7-9 weeks). Dosage: 4 mg/kg for i. v. and 20 mg/kg for p.o. (Pharmacokinetic Analysis). Administration: A single intravenousbolus or oral gavage. Result: I. v. : t1/2 = 3.39 h; AUC0-last = 107097 ng h/mL; CL = 0.621 mL/min/kg. p.o. : F = 67.2%; Cmax = 60467 ng/mL; t1/2 = 5.02 h.
• In Vitro:
  Emlenoflast, a MCC950 analogue, shows useful activity in the inhibition of activation of the NLRP3 inflammasome, with an IC50 of <100 nM.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

MCC7840

Quick Database Links

Gene Symbol

NOD