EML4-ALK kinase inhibitor 1

SKU: orb1709772

Description

EML4-ALK kinase inhibitor 1 is a potent, orally bioavailable small molecule that selectively targets the EML4-ALK fusion oncoprotein with an IC50 of 1 nM. It is widely used in preclinical research to investigate ALK-driven non-small cell lung cancer (NSCLC) in both cellular assays and animal models.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 1373409-08-5
• MW: 580.76
• Purity: 99.62% (May vary between batches)
• Formula: C₃₁H₄₈N₈O₃
• SMILES: CCc1nc(C(N)=O)c(Nc2ccc(N3CCC(CC3)N3CCN(C)CC3)c(OC)c2)nc1N[C@H]1CC[C@@H](CC1)OC
• Target: ALK
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:5 mg/mL (8.61 mM);DMSO:99 mg/mL (170.47 mM)

Bioactivity

• Target IC50:
  EML4-ALK:1 nM

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

EML4 ALK kinase inhibitor 1, EML4-​ALK kinase inhibitor 1, EML4-ALK, EML4-ALK kinase inhibitor 1

Compound Identifiers

PubChem CID

138319679