EMI1

SKU: orb2900833

Description

EMI1 is an EGFR ex19del/T790M/C797S and EGFR L858R/T790M/C797S inhibitor. EMI1 can be used for the research of mutant EGFR-associated, drug-resistant non-small-cell lung cancer (NSCLC).

Key Properties

• CAS Number: 35773-42-3
• MW: 334.37
• Purity: >98% (HPLC)
• Formula: C₂₀H₁₈N₂O₃
• SMILES: CCN(CC)C1=CC2=C(C=C1)C=C(C1=NC3=C(O1)C=CC=C3)C(=O)O2
• Target: EGFR
• Solubility: In Vitro: DMSO : 25 mg/mL (74.77 mM; Ultrasonic (<60°C)

Bioactivity

• In Vitro:
  EMI1 inhibits PC9 EGFR ex19del/T790M/C797S organoid growth with the EC50 of 131 nM. EMI1 (1 nM-10 μM) potently reduces the interaction of EGFR triple mutant with Shc1.EMI1 (1 nM-100 μM) strongly inhibits the viability and increase the caspase 3/7 activity of PC9 EGFR ex19del/T790M/C797S triple-mutant cells than noncancerous human bronchial epithelial (HBE) cells.. Cell Viability Assay Cell line: PC9 EGFR ex19del/T790M/C797S and HBE bronchial epithelial lung EGFR-WT control cells. Concentration: 0.001, 0.01, 0.1, 1, 10, 100 μM Incubation time: 72 hours. Result: Strongly inhibited the viability.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

EGFR