Emapalumab Antibody

SKU: orb1980701

Description

Emapalumab is a human IgG1 monoclonal antibody that potently neutralizes interferon-gamma (IFN-γ) by blocking its receptor interaction, thereby inhibiting pro-inflammatory signaling. It is a critical research tool for studying the pathophysiology and treatment of hemophagocytic lymphohistiocytosis (HLH), with applications in both in vitro cellular assays and in vivo disease models.

Research Area

Immunology & Inflammation, Neuroscience

Key Properties

• CAS Number: 1709815-23-5
• MW: 145.22 kDa
• Purity: 97.56% (SEC-HPLC)
• Target: IFNAR,COX

Bioactivity

• In Vitro:
  Impaired by Emapalumab (NI-0501) is the interaction between IFNcR1 and IFNc-Receptor-2 (IFNcR2) induced by IFNc at the cell surface.

Storage & Handling

• Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

IFN-γ, Emapalumab, NI 0501, NI0501, NI-0501

Quick Database Links

Gene Symbol

IFNAR,COX