Ellagic acid

SKU: orb1310586

Description

Ellagic acid (Gallogen) is a natural polyphenol and a potent, ATP-competitive CK2 inhibitor with an IC50 of 40 nM. It exhibits antioxidant and antiproliferative properties, making it a valuable research tool for studying kinase signaling, oxidative stress, and cancer biology in both cellular and animal models.

Research Area

Cardiovascular Research, Epigenetics & Chromatin, Immunology & Inflammation, Metabolism Research, Molecular Biology, Pharmacology & Drug Discovery, Signal Transduction, Stem Cell & Developmental Biology

Key Properties

• CAS Number: 476-66-4
• MW: 302.19
• Purity: 99.76% (May vary between batches)
• Formula: C₁₄H₆O₈
• SMILES: OC1=CC2=C3C(OC(=O)C4=CC(O)=C(O)C(OC2=O)=C34)=C1O
• Target: Topoisomerase,Syk,Phosphatase,Reactive Oxygen Species,Carbonic Anhydrase,PKC,Casein Kinase,ROS,Endogenous Metabolite,Hedgehog/Smoothened,PKA
• Solubility: DMSO:3.03 mg/mL (10.03 mM);10% DMSO+90% Saline:0.15 mg/mL (0.5 mM)

Bioactivity

• Target IC50:
  CK2:40 nM
• In Vivo:
  METHODS: To investigate the hepatoprotective effects on alcohol-induced liver disease (ALD), Ellagic acid (50-100 mg/kg suspended in 0.5% CMC-Na) was administered by gavage once daily for four weeks to ICR mice receiving 50% (v/v) alcohol orally daily. RESULTS: Ellagic acid attenuated oxidative stress, inflammatory response, steatosis and gut microbiota dysbiosis in ALD mice.
• In Vitro:
  METHODS: Human pancreatic cancer cell lines PANC-1, AsPC-1 and MIA PaCA-2 were treated with Ellagic acid (10-1000 µM) for 24-72 h. Cell viability was measured by MTT assay. RESULTS: The proliferation of PANC-1 was inhibited by the addition of 10 µM Ellagic acid in a dose-dependent manner. The proliferation of AsPC-1 was inhibited by the addition of 100 µM Ellagic acid, while the proliferation of MIA PaCA-2 was inhibited only by the addition of 1000 µM Ellagic acid. METHODS: Human lung cancer cells A549 were treated with Ellagic acid (5-20 µM) for 48 h, and the expression levels of target proteins were detected by Western Blot. RESULTS: Ellagic acid treatment significantly down-regulated the phosphorylation of PI3K and Akt in a dose-dependent manner.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

inhibit, Inhibitor, Hedgehog, EndogenousMetabolite, Ellagic acid, Elagostasine, Gallogen, CK2, Endogenous Metabolite, CarbonicAnhydrase, Carbonic anhydrase, Carbonic Anhydrase, Casein Kinase, CaseinKinase, ReactiveOxygenSpecies, PKC, PKA, Reactive Oxygen Species, Syk, Smoothened, Topo I

Compound Identifiers

PubChem CID

5281855