β-Elemene

SKU: orb1308896

Description

β-Elemene

Research Area

Cell Biology

Key Properties

• CAS Number: 515-13-9
• MW: 204.35
• Purity: 99.17%
• Formula: C₁₅H₂₄
• SMILES: CC(=C)[C@@H]1CC[C@@](C)(C=C)[C@@H](C1)C(C)=C
• Target: Apoptosis
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (9.79 mM);DMSO:55 mg/mL (269.15 mM)

Bioactivity

• In Vitro:
  β-Elemene significantly inhibited the metastatic capacity of MDR gastric cells in vivo and in vitro. Mechanistically, β-Elemene regulated MMP-2/9 expression and reversed epithelial-mesenchymal transition. β-Elemene upregulated Cbl-b expression, resulting in inhibition of the EGFR-ERK/AKT pathways, which regulate MMP-2/9. β-Elemene upregulated Cbl-b by inhibiting miR-1323 expression. Numbers of metastatic tumor nodules were significantly decreased in the lungs of nude mice after β-Elemene treatment. β-Elemene inhibits the metastasis of MDR gastric cancer cells by modulating the miR-1323/Cbl-b/EGFR signaling axis.
• Cell Research:
  Cell viability assay was used to assess the resistance of SGC7901/ADR cells and the cytotoxic effects of β-Elemene. Wound healing, transwell assay and lung metastatic mice model were used to the anti-metastasis effects of β-Elemene. MicroRNA microarray analysis was used to explore potential regulated miRNAs. Luciferase reporter assay was used to identify the direct target. Human MMP antibody array, western blot, immunoprecipitation, qRT-PCR analyses and immunohistochemistry were conducted to investigate the underlying anti-metastasis mechanism of β-Elemene.

Storage & Handling

• Storage: store under nitrogen | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

βElemene, β-Elemene, β Elemene, Inhibitor, inhibit, Levo-β-elemene, Levo-b-elemene, Levo-beta-elemene, b-Elemene, beta-Elemene, (-)-β-Elemene, Apoptosis

Compound Identifiers

PubChem CID

6918391