β-Elemene

SKU: orb1219367

Description

β-Elemene is a natural product isolated from Curcuma wenyujin, with an antitumor activity and induce cell apoptosis.β-Elemene significantly inhibited the metastatic capacity of MDR gastric cells in vivo and in vitro. Mechanistically, β-Elemene regulated MMP-2/9 expression and reversed epithelial-mesenchymal transition. β-Elemene upregulated Cbl-b expression, resulting in inhibition of the EGFR-ERK/AKT pathways, which regulate MMP-2/9. β-Elemene upregulated Cbl-b by inhibiting miR-1323 expression. Numbers of metastatic tumor nodules were significantly decreased in the lungs of nude mice after β-Elemene treatment. β-Elemene inhibits the metastasis of MDR gastric cancer cells by modulating the miR-1323/Cbl-b/EGFR signaling axis.

Key Properties

• CAS Number: 515-13-9
• MW: 204.35
• Purity: >98% (HPLC)
• Formula: C₁₅H₂₄
• SMILES: CC([C@H]1[C@@](C)(CC[C@@H](C(C)=C)C1)C=C)=C
• Target: Apoptosis
• Solubility: DMSO:50 mg/mL (244.68 mM; Need ultrasonic)

Bioactivity

• In Vitro:
  Cell Viability Assay Cell line: T24, 5637, TCCSUP, J82, UM-UC-3, RT4 and SW780 cells. Concentration: 0, 6.25, 12.5, 25, 50, 100, 150 and 200 μg/ml Incubation time: 24 hours. Result: Inhibited the proliferation of RT4, SW780, J82, UMUC-3, TCCSUP, 5637 and T24 human bladder cancer cells and SV-HUC-1 human urothelial cells. Cell Cycle Analysis Cell line: T24 and 5637 cells. Concentration: 0, 25, 50 and 75 μg/ml. Incubation time: 24 hours. Result: Induced the percentage of cells in the S-phase as a dose-dependent manner. Western blot analysis. Cell line: T24 cells. Concentration: 50 μg/ml. Incubation time: 24 hours. Result: Downregulated p-STAT3 and cell cycle-related proteins.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

(-)-β-Elemene,Levo-β-elemene

Quick Database Links

Gene Symbol

Apoptosis