Eleclazine

SKU: orb1737549

Description

Eleclazine (GS-6615) is a selective late sodium current (INaL) inhibitor with antiarrhythmic properties. It is used in research to study cardiac arrhythmia mechanisms and has been investigated in preclinical models for conditions like long QT syndrome and heart failure.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 1443211-72-0
• MW: 415.37
• Purity: 98.67% (May vary between batches)
• Formula: C₂₁H₁₆F₃N₃O₃
• SMILES: O=C1C2=CC(=CC=C2OCCN1CC3=NC=CC=N3)C=4C=CC(OC(F)(F)F)=CC4
• Target: Sodium Channel,Potassium Channel

Bioactivity

• In Vitro:
  In isolated failing rabbit hearts with ischemia-reperfusion injury, Eleclazine (1 μM, 20 min perfusion) reduced APD dispersion and accelerated intracellular Ca²⁺ clearance, suppressing arrhythmogenic alternans. Under therapeutic hypothermia (33 °C, 30 min), Eleclazine further improved outcomes by reducing ventricular fibrillation (VF) inducibility and severity.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

SCR1693, SCR-1693, Eleclazine, Eleclazine free base, GS6615, GS-6615

Compound Identifiers

PubChem CID

71183216