Eleclazine hydrochloride

SKU: orb1308345

Description

Eleclazine hydrochloride (GS 6615 hydrochloride) is a selective late sodium current inhibitor with an IC50 of 0.7 µM. It is a research tool used in cardiovascular studies, particularly for investigating arrhythmias and heart failure in both in vitro and in vivo experimental models.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 1448754-43-5
• MW: 451.83
• Purity: 98.95%
• Formula: C₂₁H₁₇ClF₃N₃O₃
• SMILES: Cl.FC(F)(F)Oc1ccc(cc1)-c1ccc2OCCN(Cc3ncccn3)C(=O)c2c1
• Target: Sodium Channel,Potassium Channel
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (8.85 mM);DMSO:100 mg/mL (221.32 mM)

Bioactivity

• Target IC50:
  Na+ current:0.7 uM
• In Vitro:
  Inhibition by GS-6615 of ATX-II enhanced late INa is potently correlated with shortening of myocyte APD and isolated heart MAPD. Eleclazine hydrochloride inhibits ATX-II enhanced late INa in ventricular myocytes, shorten the ATX-II induced prolongation of APD, MAPD, QT interval. It also decreased spatiotemporal dispersion of repolarization and ventricular arrhythmias. Selective inhibition of cardiac late INa with eleclazine hydrochloride confers dual protection against vulnerability to ischemia-induced AF. That decreases atrial and ventricular repolarization abnormalities before and during adrenergic stimulation without negative inotropic effects.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

cardiac arrhythmias, atrial premature beats, KcsA, Inhibitor, inhibit, Na channels, Na+ channels, Na+ current, epinephrine, Eleclazine, Eleclazine Hydrochloride, Eleclazine hydrochloride, GS6615, GS-6615, GS6615 Hydrochloride, GS-6615 Hydrochloride, GS 6615, GS 6615 hydrochloride, GS 6615 Hydrochloride, hiPSC, SodiumChannel, Sodium Channel, porcine, Potassium Channel

Compound Identifiers

PubChem CID

90479986