EHMT1 (C) Antibody, Rabbit Polyclonal

• Catalog Number: orb66842
• Category: Antibodies
• Description: Rabbit polyclonal to EHMT1.EHMT1 is a Histone-lysine N-methyltransferase that specifically mono-and dimethylates 'Lys-9' ofhistone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin. H3K9me represents a specific tagfor epigenetic transcriptional repression by recruiting HP1 proteins to methylated histones. EHMT1also weakly methylates 'Lys-27' of histone H3 (H3K27me). EHMTa is also required for DNAmethylation independent of its histone methyltransferase. During G0 phase, EHMT1 contributes tosilencing of MYC-and E2F-responsive genes, suggesting a role in G0/G1 transition in cell cycle. Inaddition to the histone methyltransferase activity, EHMT1 also methylates non-histone proteins, suchas the dimethylation of 'Lys-373' of p53/TP53.
• Clonality: Polyclonal
• Species/Host: Rabbit
• Conjugation: Unconjugated
• Reactivity: Human
• Buffer/Preservatives: 0.01% NaN3
• Purity: Affinity purification
• Immunogen: C-terminal region of human EHMT1
• UniProt ID: Q9H9B1
• MW: 141
• Tested applications: WB
• Dilution range: WB:1:1000-1:5000
• Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
• Alternative names: anti-EHMT1 antibody,anti-Histonelysine Nmethyltran
• Research Area: Epigenetics
• Note: For research use only

Western blot analysis of total cell extracts from human Hela using EHMT1 antibody