EHMT1 (C) Antibody, Rabbit Polyclonal

• Catalog Number: orb66842
• Category: Antibodies
• Description: Rabbit polyclonal to EHMT1.EHMT1 is a Histone-lysine N-methyltransferase that specifically mono-and dimethylates 'Lys-9' ofhistone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin. H3K9me represents a specific tagfor epigenetic transcriptional repression by recruiting HP1 proteins to methylated histones. EHMT1also weakly methylates 'Lys-27' of histone H3 (H3K27me). EHMTa is also required for DNAmethylation independent of its histone methyltransferase. During G0 phase, EHMT1 contributes tosilencing of MYC-and E2F-responsive genes, suggesting a role in G0/G1 transition in cell cycle. Inaddition to the histone methyltransferase activity, EHMT1 also methylates non-histone proteins, suchas the dimethylation of 'Lys-373' of p53/TP53.
• Species/Host: Rabbit
• Clonality: Polyclonal
• Tested applications: WB
• Reactivity: Human
• Immunogen: C-terminal region of human EHMT1
• Dilution range: WB:1:1000-1:5000
• Purity: Affinity purification
• Conjugation: Unconjugated
• MW: 141
• UniProt ID: Q9H9B1
• Storage: -20°C
• Buffer/Preservatives: 0.01% NaN3
• Alternative names: anti-EHMT1 antibody,anti-Histonelysine Nmethyltran
• Note: For research use only
• Expiration Date: 12 months from date of receipt.

Western blot analysis of total cell extracts from human Hela using EHMT1 antibody