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EGFR kinase inhibitor 4

SKU: orb2566342

Description

EGFR Kinase Inhibitor 4 is a potent bivalent ATP-allosteric inhibitor of mutant EGFR (L858R/T790M/C797S), exhibiting an IC50 of 1.8 nM. It is a key research tool for investigating resistance mechanisms and therapeutic strategies in non-small cell lung cancer (NSCLC) models, both in vitro and in vivo.

Research Area

Cardiovascular Research, Pharmacology & Drug Discovery; Cell Biology, Signal Transduction

Images & Validation

Key Properties

CAS Number2922402-05-7
MW690.75
FormulaC40H34N8O4
SMILESC(C)C=1NC(=C(N1)C2=CC(NC(=O)C3=C4C(NC=5C(C(=O)N4)=CC=CC5)=CC=C3)=CC=C2)C=6C=C(NC7=C(OC)C=CC(NC(C=C)=O)=C7)N=CC6
TargetEGFR

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

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Quality Guarantee

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at [email protected].

Key Properties

No computed properties available.

Protocol Information