EGFR kinase inhibitor 4

SKU: orb2566342

Description

EGFR Kinase Inhibitor 4 is a potent bivalent ATP-allosteric inhibitor of mutant EGFR (L858R/T790M/C797S), exhibiting an IC50 of 1.8 nM. It is a key research tool for investigating resistance mechanisms and therapeutic strategies in non-small cell lung cancer (NSCLC) models, both in vitro and in vivo.

Research Area

Cardiovascular Research, Pharmacology & Drug Discovery; Cell Biology, Signal Transduction

Key Properties

• CAS Number: 2922402-05-7
• MW: 690.75
• Formula: C₄₀H₃₄N₈O₄
• SMILES: C(C)C=1NC(=C(N1)C2=CC(NC(=O)C3=C4C(NC=5C(C(=O)N4)=CC=CC5)=CC=C3)=CC=C2)C=6C=C(NC7=C(OC)C=CC(NC(C=C)=O)=C7)N=CC6
• Target: EGFR

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

171038205