MAZ51

SKU: orb1298884

Description

MAZ51 is a selective small molecule inhibitor targeting the VEGFR-3 (Flt-4) tyrosine kinase. It is utilized in research to investigate lymphangiogenesis and tumor metastasis in both cellular and animal models, providing a tool to study VEGF-C/VEGF-D signaling pathways.

Research Area

Cardiovascular Research, Cell Biology, Signal Transduction

Key Properties

• CAS Number: 163655-37-6
• MW: 314.38
• Purity: 98.53%
• Formula: C₂₁H₁₈N₂O
• SMILES: CN(C)c1ccc(\C=C2\C(=O)Nc3ccccc23)c2ccccc12
• Target: Apoptosis,VEGFR
• Solubility: DMSO:3.33 mg/mL (10.59 mM)

Bioactivity

• In Vivo:
  In vivo, MAZ51 significantly inhibits the growth of rat mammary carcinomas. These data establish MAZ51 as a compound with antitumor properties that inhibits tumor growth directly and also indirectly by interfering with tumor-host interactions.
• In Vitro:
  MAZ51 is able to block the proliferation of VEGFR-3-expressing human endothelial cells and is less potently able to induce their apoptosis. MAZ51 also inhibits the proliferation and induces the apoptosis of a variety of non-VEGFR-3-expressing tumor cell lines.

Storage & Handling

• Storage: Powder: -20°C for 3 years | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Apoptosis, EGFR, growth, IGF-1R, MAZ 51, MAZ51, MAZ-51, ligand-induced, Inhibitor, inhibit, indolinone, PDGFRβ, phosphorylation, proliferation, tumor, Vascular endothelial growth factor receptor, VEGF-C, VEGF-D, VEGFR, VEGFR3

Compound Identifiers

PubChem CID

53230017