eCF506

SKU: orb1298881

Description

eCF506 is a highly potent and selective SRC kinase inhibitor with sub-nanomolar activity (IC50 < 0.5 nM). This compound is a valuable research tool for investigating SRC-related signaling pathways in cancer and other diseases, applicable in both cellular and biochemical assays.

Research Area

Cardiovascular Research, Signal Transduction

Key Properties

• CAS Number: 1914078-41-3
• MW: 510.63
• Purity: 99.29% (May vary between batches)
• Formula: C₂₆H₃₈N₈O₃
• SMILES: COc1cc(ccc1NC(=O)OC(C)(C)C)-c1nn(CCN2CCC(CC2)N(C)C)c2ncnc(N)c12
• Target: Src
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (3.92 mM);DMSO:52.5 mg/mL (102.81 mM)

Bioactivity

• Target IC50:
  Src:< 0.5 nM)|MDA-MB-231 cells:9 nM (EC50)|yes:2.1 nM
• In Vivo:
  METHODS: Immunodeficient Rag2-Il2rg double knockout mice were implanted with PX459v2 and ILK gRNA 2 tumors and then given bosutinib (75 mg/kg) or eCF506 (40 mg/kg) once daily by oral gavage, and tumor volume growth was observed. RESULTS eCF506 treatment completely blocked the growth of ILK gRNA and PX459v2 tumors in the mouse model.
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• In Vitro:
  eCF506 can inhibit tyrosine kinase Src with IC50 value less than 0.5 nM.

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Inhibitor, eCF506, eCF-506, eCF 506, inhibit, Src

Compound Identifiers

PubChem CID

121231408