eCF506

SKU: orb1220119

Description

eCF506 is a potent and selective inhibitor of SRC (IC50 < 0.5 nM)eCF506, the first small molecule with subnanomolar IC50 for SRC that requires 3 orders of magnitude greater concentration to inhibit ABL. eCF506 exhibits excellent water solubility, an optimal DMPK profile and oral bioavailability, halts SRC-associated neuromast migration in zebrafish embryos without inducing life-threatening heart defects, and inhibits SRC phosphorylation in tumor xenografts in mice.

Key Properties

• CAS Number: 1914078-41-3
• MW: 510.63
• Purity: >98% (HPLC)
• Formula: C₂₆H₃₈N₈O₃
• SMILES: COc1cc(ccc1NC(=O)OC(C)(C)C)-c1nn(CCN2CCC(CC2)N(C)C)c2ncnc(N)c12
• Target: Src
• Solubility: DMSO:62.5 mg/mL (122.40 mM; Need ultrasonic)

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Src