Ebselen

SKU: orb1224475

Description

Ebselen is a mimic of glutathione peroxidase and can also react with peroxynitrite. It is being investigated as a possible treatment for reperfusion injury and stroke, hearing loss and tinnitus, and bipolar disorder.(In Vitro):Ebselen (SPI-1005; 0.4-100 μM; 20-24 hours) shows strong antiviral effects at a concentration of 10 μM treatment in COVID-19 virus infected Vero cells. Ebsele covalently binds to C145 of the catalytic dyad in COVID-19 virus Mpro.Ebselen inhibits early viral postentry events of the HIV-1 life cycle by impairing the incoming capsid uncoating process.Ebselen permeates the blood-brain barrier and inhibits endogenous inositol monophosphatase in mouse brain. Ebselen inhibits inositol monophosphatase (IMPase).Ebselen inhibits QSOX1 enzymatic activity and suppresses invasion of pancreatic, renal cancer cell lines.(In Vivo):Ebselen (5, 10 mg/kg; IP) decreases 5-HT2 agonist-induced head twitches in a dose-dependent manner.

Key Properties

• CAS Number: 60940-34-3
• MW: 274.18
• Purity: >98% (HPLC)
• Formula: C₁₃H₉NOSe
• SMILES: O=C1N(C2=CC=CC=C2)[Se]C3=CC=CC=C13
• Target: COX
• Solubility: Water: 10 mM

Bioactivity

• In Vivo:
  Ebselen (5, 10 mg/kg; IP) decreases 5-HT2 agonist-induced head twitches in a dose-dependent manner. Animal model: 20-25 g 10-12 week old male C57Bl6 mice. Dosage: 5, 10 mg/kg. Administration: IP. Result: Decreased 5-HT2 agonist-induced head twitches in a dose-dependent manner.
• In Vitro:
  Ebselen (SPI-1005; 0.4-100 μM; 20-24 hours) shows strong antiviral effects at a concentration of 10 μM treatment in COVID-19 virus infected Vero cells. Ebsele covalently binds to C145 of the catalytic dyad in COVID-19 virus Mpro. Ebselen inhibits early viral postentry events of the HIV-1 life cycle by impairing the incoming capsid uncoating process. Ebselen permeates the blood-brain barrier and inhibits endogenous inositol monophosphatase in mouse brain. Ebselen inhibits inositol monophosphatase (IMPase). Ebselen inhibits QSOX1 enzymatic activity and suppresses invasion of pancreatic, renal cancer cell lines. RT-PCR Cell line: COVID-19 virus infected Vero cells. Concentration: 0.4, 1.2, 3.7, 11.1, 33.3, 100 μM Incubation time: 20-24 hours. Result: Showed strong antiviral effects at a concentration of 10 μM treatment.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

SPI-1005 | SPI1005 | SPI 1005 | Ebselen | PZ 51 | PZ51 | PZ-51 | DR3305 | DR 3305 | DR-3305

Quick Database Links

Gene Symbol

COX