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EAI001

SKU: orb2900827

Description

EAI001 is a potent, selective mutant epidermal growth factor receptor (EGFR) allosteric inhibitor with an IC50 value of 24 nM for EGFRL858R/T790M. EAI001 can be used for research of cancer.

Images & Validation

Key Properties

CAS Number892772-75-7
MW349.41
Purity>98% (HPLC)
FormulaC19H15N3O2S
SMILESO=C(Nc1nccs1)C(N1Cc2ccccc2C1=O)c1ccccc1
TargetEGFR
SolubilityIn Vitro: DMSO : 100 mg/mL (286.20 mM; Ultrasonic )

Bioactivity

In Vitro
EAI001 (50 μM) binds to EGFR T790M/C797S/V948R that lies deep inside the EGFR towards the ATP binding site and C-helix. EAI001 showed inhibitory activity due to hydrophobic interaction with amino acid Ile759, Leu747, Leu788, Leu777 and Met766.

Storage & Handling

StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

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    892772-75-7

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    C19H15N3O2S

    50 mg, 5 mg, 10 mg, 25 mg, 100 mg
Quality Guarantee

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Protocol Information

EAI001 (orb2900827)

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% DMSO +
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% Tween 80 +
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Available Sizes

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500 mg
5 mg
$ 90.00
10 mg
$ 140.00
25 mg
$ 230.00
50 mg
$ 370.00
100 mg
$ 560.00