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EAI001

SKU: orb1688847

Description

EAI001

Research Area

Cardiovascular Research, Signal Transduction

Images & Validation

Key Properties

CAS Number892772-75-7
MW349.41
Purity99.94%
FormulaC19H15N3O2S
SMILESO=C(Nc1nccs1)C(N1Cc2ccccc2C1=O)c1ccccc1
TargetEGFR
SolubilityDMSO:90 mg/mL (257.58 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (9.44 mM)

Bioactivity

Target IC50
EGFR (L858R/T790M):24 nM
In Vitro
EAI001 (50 μM) exhibits binding to EGFR T790M/C797S/V948R, situated deep within the EGFR near the ATP binding site and the C-helix. The inhibitory activity of EAI001 is attributed to its hydrophobic interactions with amino acids Ile759, Leu747, Leu788, Leu777, and Met766.

Storage & Handling

StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

EGFR (T790M)

Similar Products

  • EAI001 [orb2900827]

    >98% (HPLC)

    892772-75-7

    349.41

    C19H15N3O2S

    5 mg, 10 mg, 25 mg, 50 mg, 100 mg, 1 g, 500 mg
Quality Guarantee

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Key Properties

No computed properties available.

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EAI001 (orb1688847)

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% DMSO +
%+
% Tween 80 +
%

Available Sizes

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5 mg
$ 100.00
10 mg
$ 130.00
25 mg
$ 220.00
50 mg
$ 340.00
100 mg
$ 520.00
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