Queen's Award Received in 2021 ISO 9001 Certified Delivered over 1,000,000 bio-reagents to life science researchers Trusted by Life Science Communities
Cart summary

You have no items in your shopping cart.

E6446

SKU: orb1303063

Description

E6446 is a small molecule inhibitor of Toll-like receptors 7 and 9 (TLR7/9) that blocks DNA-TLR9 interaction in vitro. In vivo, it suppresses immune responses to CpG DNA challenge in mice, making it a useful research tool for studying TLR signaling in autoimmunity and inflammation models.

Research Area

Immunology & Inflammation, Metabolism Research

Images & Validation

Key Properties

CAS Number1219925-73-1
MW449.59
Purity99.99% (May vary between batches)
FormulaC27H35N3O3
SMILESO(CCCN1CCCC1)C=2C=C3C(N=C(O3)C4=CC=C(OCCCN5CCCC5)C=C4)=CC2
TargetStearoyl-CoA Desaturase (SCD),TLR
SolubilityDMSO:9 mg/mL (20.02 mM);10% DMSO+40% PEG300+5% Tween-80+45% Saline:0.5 mg/mL (1.11 mM)

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

E6446, E-6446, E 6446, TLR7, TLR9

Similar Products

  • E6446 dihydrochloride [orb1303204]

    99.44% (May vary between batches)

    1345675-25-3

    522.51

    C27H37Cl2N3O3

    10 mg, 1 mg, 25 mg, 100 mg, 2 mg, 5 mg, 50 mg, 1 ml x 10 mM (in DMSO)
  • E6446 dihydrochloride [orb1223340]

    >98% (HPLC)

    1345675-25-3

    522.51

    C27H37Cl2N3O3

    2 mg, 5 mg, 10 mg, 25 mg, 50 mg, 100 mg, 200 mg, 500 mg, 1 g
  • E6446 [orb1223385]

    >98% (HPLC)

    1219925-73-1

    449.6

    C27H35N3O3

    2 mg, 5 mg, 10 mg, 25 mg, 100 mg, 200 mg, 500 mg, 1 g
Quality Guarantee

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at [email protected].

Key Properties

No computed properties available.

Protocol Information

Available Sizes

Select a size below

1 mg
$ 130.00
5 mg
$ 240.00
10 mg
$ 370.00
25 mg
$ 580.00
50 mg
$ 810.00
100 mg
$ 1,090.00
DispatchUsually dispatched within 5-10 working days
Bulk Enquiry