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E6446 dihydrochloride

SKU: orb1223340

Description

E6446 dihydrochloride is a novel synthetic antagonist for nucleic acid-sensing TLRs; potently suppressed DNA stimulation of HEK:TLR9 cells with IC50 of 10 nM.

Images & Validation

Key Properties

CAS Number1345675-25-3
MW522.51
Purity>98% (HPLC)
FormulaC27H37Cl2N3O3
SMILESc1(c2ccc(OCCCN3CCCC3)cc2)nc2ccc(OCCCN3CCCC3)cc2o1.Cl.Cl
Targetp38 MAPK
SolubilityIn Vitro: DMSO : 7.6 mg/mL (14.55 mM)

Storage & Handling

StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Similar Products

  • E6446 dihydrochloride [orb1303204]

    98.44% (May vary between batches)

    1345675-25-3

    522.51

    C27H37Cl2N3O3

    1 ml x 10 mM (in DMSO), 2 mg, 10 mg, 50 mg, 1 mg, 25 mg, 100 mg, 5 mg
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Protocol Information

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200 mg
500 mg
2 mg
$ 270.00
5 mg
$ 510.00
10 mg
$ 620.00
25 mg
$ 1,030.00
50 mg
$ 1,460.00
100 mg
$ 1,970.00