E3 ligase Ligand 22

SKU: orb2566368

Description

E3 Ligase Ligand 22 (compound 139) is a cereblon-binding molecule that induces the ubiquitin-proteasomal degradation of transcription factors Ikaros and Aiolos. This mechanism of action makes it a valuable chemical probe for targeted protein degradation research in both cellular and in vivo models of hematological cancers.

Research Area

Molecular Biology, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 2377849-57-3
• MW: 518.61
• Formula: C₂₈H₃₄N₆O₄
• SMILES: N(CC1=CN(N=C1)C2CCN(CC3(C)CCC3)CC2)C4=C5C(C(=O)N(C5=O)C6C(=O)NC(=O)CC6)=CC=C4
• Target: Ligands for E3 Ligase

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

155469840