Dynasore

SKU: orb1307332

Description

Dynasore is a reversible, non-competitive inhibitor of dynamin 1/2 GTPase activity (IC50 = 15 µM) and the mitochondrial dynamin Drp1. This cell-permeable compound is a valuable research tool for studying clathrin-mediated endocytosis and mitochondrial fission pathways in both cellular and biochemical assays.

Research Area

Cell Biology

Key Properties

• CAS Number: 304448-55-3
• MW: 322.32
• Purity: >98%
• Formula: C₁₈H₁₄N₂O₄
• SMILES: Oc1ccc(C=NNC(=O)c2cc3ccccc3cc2O)cc1O
• Target: GTPase
• Solubility: Soluble in DMSO (up to 30 mg/ml), or in Ethanol (up to 1 mg/ml).

Bioactivity

• Target IC50:
  Dynamin1/2:15 μM|moderate potenc:~15 μM (vitro)
• In Vivo:
  Dynasore significantly ameliorates motor dysfunction in rats at 3, 7, and 10 days post-SCI, potentially through the inhibition of neuronal mitochondrial apoptotic pathway activation and astrocytic proliferation .
• Cell Research:
  Mouse ventricular myocytes are isolated from male adult C6/Black mouse. Cardiomyocytes subjects to 2 hours of drug treatment followed by oxidative stress (30 μM Water2 for 35 min). For ATP supplement experiments, the cells are treated with 3 mM ATP for 30 min before exposure to Water2. Cardiomyocyte survival and viability are analyzed by trypan blue exclusion (TBE) assay.

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Virus Protease, VirusProtease, Herpes simplex virus, HSV, Inhibitor, inhibit, Autophagy, Dynamin, Dynamin Inhibitor I, Dynamin1/2, Dynasore

Compound Identifiers

PubChem CID

708101