Hydroxy-Dynasore

SKU: orb1300434

Description

Hydroxy-Dynasore

Research Area

Signal Transduction

Key Properties

• CAS Number: 1256493-34-1
• MW: 338.31
• Purity: 97.60%
• Formula: C₁₈H₁₄N₂O₅
• SMILES: Oc1cc(O)c(\C=N\NC(=O)c2cc3ccccc3cc2O)cc1O
• Target: Dynamin
• Solubility: DMSO:45 mg/mL (133.01 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.91 mM)

Bioactivity

• Target IC50:
  DynI (rec):1.1 μM|DynI (brain):0.38 μM|DynII (rec):2.3 μM
• In Vitro:
  Dyngo-4a inhibits dynamin-dependent endocytosis of transferrin in multiple cell types with IC of 5.7 μM, and reduces synaptic vesicle endocytosis and activity-dependent bulk endocytosis in cultured neurons and synaptosomes. In motor nerve terminals and cultured hippocampal neurons, Dyngo-4a blocks Alexa Fluor 488-BoNT/A-Hc internalization. In Drosophila S2R+ cells, Dyngo-4a causes a decrease in the level of Armadillo/β-catenin.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Neuron, inhibit, Inhibitor, HydroxyDynasore, Hydroxy-Dynasore, Hydroxy Dynasore, Endocytosis,Dynamin,GTPase, Dyngo-4a, DynI (brain), DynI (rec), DynII (rec), Dynamin, clathrin‐coated, vesicle

Compound Identifiers

PubChem CID

136227923