DU-14 (PTP1B/TC-PTP PROTAC)

SKU: orb2814181

Description

DU-14 (PTP1B/TC-PTP PROTAC) is a potent, selective dual degrader of PTP1B and TC-PTP phosphatases, with IC50 values of 24.2 nM and 30.1 nM, respectively. It enhances IFN-γ signaling and T cell activation, demonstrating antitumor potential in research applications for immuno-oncology and inflammation studies.

Research Area

Pharmacology & Drug Discovery, Signal Transduction, Stem Cell & Developmental Biology

Key Properties

• CAS Number: 3053413-58-1
• MW: 1505.46
• Formula: C₇₄H₈₅BrF₂N₉O₁₄PS
• SMILES: C([C@@H](NC(CC1=CC(CNC([C@@H](NC([C@H](CC2=CC=C(C(P(=O)(O)O)(F)F)C=C2)NC([C@H](CC3=CC=CC=C3)NC(CC4=CC(OC)=C(O)C=C4)=O)=O)=O)CCCCNC(=O)C5=CC(Br)=C(C)C=C5)=O)=CC=C1)=O)C(C)(C)C)(=O)N6[C@H](C(N[C@@H](C)C7=CC=C(C=C7)C8=C(C)N=CS8)=O)C[C@@H](O)C6
• Target: PROTACs,STAT

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

172263112