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Donitriptan

SKU: orb1309750

Description

Donitriptan is a potent and selective agonist for 5-HT1B and 5-HT1D receptors, exhibiting pKi values of 9.4 and 9.3, respectively. This compound is a valuable research tool for studying serotonergic pathways in models of migraine and neurovascular disorders, applicable in both in vitro and in vivo experimental settings.

Research Area

Neuroscience, Pharmacology & Drug Discovery

Images & Validation

Key Properties

CAS Number170912-52-4
MW403.48
Purity98.76% (May vary between batches)
FormulaC23H25N5O2
SMILESNCCc1c[nH]c2ccc(OCC(=O)N3CCN(CC3)c3ccc(cc3)C#N)cc12
Target5-HT Receptor
Solubility10% DMSO+40% PEG300+5% Tween-80+45% Saline:3.3 mg/mL (8.18 mM);DMSO:245 mg/mL (607.22 mM)

Bioactivity

Target IC50
pki:|5-HT1B receptor:9.4 (pki)|5-HT1D receptor:9.3 (pki)

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

inhibit, Inhibitor, 5-HT1B, 5-HT1D, 5-HT1D Receptor, 5-HT1B Receptor, 5-HT Receptor, 5HT Receptor, 5-hydroxytryptamine Receptor, 5HTReceptor, Donitriptan, pki, Serotonin Receptor

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Quality Guarantee

Quality Guarantee

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Key Properties

No computed properties available.

Protocol Information

Available Sizes

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1 ml x 10 mM (in DMSO)
$ 180.00