Donitriptan hydrochloride

SKU: orb1306246

Description

Donitriptan hydrochloride is a potent and efficacious agonist at 5-HT1B and 5-HT1D receptors, with pKi values of 9.4 and 9.3. It is utilized in research to study migraine pathophysiology and serotonin receptor signaling in both in vitro binding assays and in vivo models.

Research Area

Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 170911-68-9
• MW: 439.94
• Purity: 99.86% (May vary between batches)
• Formula: C₂₃H₂₆ClN₅O₂
• SMILES: Cl.N#CC1=CC=C(C=C1)N2CCN(C(=O)COC=3C=CC=4NC=C(C4C3)CCN)CC2
• Target: 5-HT Receptor
• Solubility: DMSO:4.4 mg/mL (10 mM)

Bioactivity

• Target IC50:
  5-HT1B receptor:9.4 (pKi)|5-HT1D receptor:9.3 (pKi)

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

5HT Receptor, 5HTReceptor, 5-HT, Donitriptan, Donitriptan HCl, Donitriptan Hydrochloride, Donitriptan Monohydrochloride, Donitriptan monohydrochloride

Compound Identifiers

PubChem CID

197705