DNA2 inhibitor C5

SKU: orb1308373

Description

DNA2 inhibitor C5 is a specific, competitive small-molecule inhibitor of DNA2 nuclease activity (IC50: 20 µM) that also blocks its ATPase, helicase, and DNA-binding functions. This compound serves as a research tool to study DNA replication stress and is used in vitro to sensitize cancer cells to chemotherapeutic agents.

Research Area

Cell Biology, Epigenetics & Chromatin; Pharmacology & Drug Discovery, Molecular Biology

Key Properties

• CAS Number: 35973-25-2
• MW: 234.16
• Purity: 98.00% (May vary between batches)
• Formula: C₁₀H₆N₂O₅
• SMILES: OC(=O)c1cnc2c(cccc2c1O)[N+]([O-])=O
• Target: Others,DNA/RNA Synthesis
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (8.54 mM);DMSO:31.25 mg/mL (133.46 mM)

Bioactivity

• Target IC50:
  DNA2 nuclease:20 μM

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

DNA2 inhibitor C5, DNA-2 inhibitor C5, DNA2 nuclease, inhibit, Inhibitor

Compound Identifiers

PubChem CID

225906