DNA2 inhibitor C5

SKU: orb1218108

Description

DNA2 inhibitor C5 is a promising lead compound to develop sensitizers for cancer chemotherapeutics that cause replication stress and it also is a competitive and specific inhibitor of DNA2 nuclease activity (IC50: 20 μM). DNA2 inhibitor C5 inhibits nuclease, DNA dependent ATPase, helicase, and DNA binding activities of DNA2.

Research Area

Epigenetics & Chromatin; Pharmacology & Drug Discovery

Images & Validation

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Key Properties

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CAS Number	35973-25-2
MW	234.17
Purity	>98% (HPLC)
Formula	C₁₀H₆N₂O₅
SMILES	O=C(C1=C(O)C2=CC=CC([N+]([O-])=O)=C2N=C1)O
Target	DNA2 nuclease
Solubility	DMSO:31.25 mg/mL (133.45 mM; Need ultrasonic)

Storage & Handling

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Storage	Storage temperature: -20°C. Stability: ≥ 2 years
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

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Gene Symbol

DNA2 nuclease

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